L-type calcium channel blockers may contribute to heart failure, study finds

(Penn State) Researchers found that in rats and human cells in vitro, LCCBs cause changes in blood vessels -- known as vascular remodeling -- that reduce blood flow and increase pressure. Examining epidemiological data, the team also found that LCCBs are associated with a greater risk for heart failure. The findings suggest that care should be taken when prescribing these drugs to patients, particularly older adults and those with advanced hypertension.